N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
Based on 1 Customer Validation
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine can serve as an intermediate for oligonucleotide synthesis.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 64325-78-6
- Formula: C38H35N5O6
- Molecular Weight:657.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
In Vitro
Oligonucleotides are a class of short-chain nucleic acids composed of deoxyribonucleotides or ribonucleotides; by adhering to the principle of complementary base pairing, they can pair with DNA, mRNA, or pre-mRNA to precisely "silence" specific genes, thereby inhibiting the expression of numerous proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 64325-78-6
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Appearance Solid
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Molecular Weight 657.71
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Formula C38H35N5O6
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C(N=CN=C3NC(C4=CC=CC=C4)=O)=C3N=C2)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (152.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (250 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5204 mL | 7.6021 mL | 15.2043 mL | 38.0107 mL |
| 5 mM | 0.3041 mL | 1.5204 mL | 3.0409 mL | 7.6021 mL | |
| 10 mM | 0.1520 mL | 0.7602 mL | 1.5204 mL | 3.8011 mL | |
| 15 mM | 0.1014 mL | 0.5068 mL | 1.0136 mL | 2.5340 mL | |
| 20 mM | 0.0760 mL | 0.3801 mL | 0.7602 mL | 1.9005 mL | |
| 25 mM | 0.0608 mL | 0.3041 mL | 0.6082 mL | 1.5204 mL | |
| 30 mM | 0.0507 mL | 0.2534 mL | 0.5068 mL | 1.2670 mL | |
| 40 mM | 0.0380 mL | 0.1901 mL | 0.3801 mL | 0.9503 mL | |
| 50 mM | 0.0304 mL | 0.1520 mL | 0.3041 mL | 0.7602 mL | |
| 60 mM | 0.0253 mL | 0.1267 mL | 0.2534 mL | 0.6335 mL | |
| 80 mM | 0.0190 mL | 0.0950 mL | 0.1901 mL | 0.4751 mL | |
| 100 mM | 0.0152 mL | 0.0760 mL | 0.1520 mL | 0.3801 mL |
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine Related Classifications
HY-W013077 Related Classifications
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