2. Metabolic Enzyme/Protease
  3. PAI-1
  4. Kinase, Natto fermentation

Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No. : 133876-92-3

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Based on 4 publication(s) in Google Scholar

Kinase, Natto fermentation Related Antibodies

Top Publications Citing Use of Products

    Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.

    Cells were exposed to different concentrations of nattokinase for various durations, after which cell viability was measured.

    Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.

    Cells were pretreated with Kinase, Natto fermentation for 1 hour, then exposed to PM, and then (B) COX-2 protein expression was detected.

    Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.

    Cells were pretreated with NAC, APO, DPI, or natto kinase (Natto fermentation) for 1 hour, then exposed to PM, and Akt phosphorylation was detected.

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    Description

    Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases[1].

    In Vitro

    Kinase, Natto fermentation dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2].
    Product Information
    Molecular weight: 27728 Da (a single-chain polypeptide enzyme composed of 275 amino acids in a fixed arrangement) Acidity and alkalinity: relatively stable in neutral or alkaline environment (pH 7.0 ~12.0), extremely unstable when pH <5.0. However, the stability of nattokinase is greatly improved after mixing with boiled rice extract, broth, serum protein and gastric juice protein, and the enzyme activity will not be completely lost even under acidic conditions.
    Temperature: sensitive to high temperature, with better stability below 37°C, and it will be quickly inactivated due to protein denaturation when the temperature is higher than 60°C. Freeze-thaw: After repeated freeze-thaw cycles for 5 times, 95% of the original activity can still be retained.

    Instructions

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Kinase, Natto fermentation Related Antibodies
    In Vivo

    Kinase, Natto fermentation (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3]
    Dosage: 150, 250 mg/kg
    Administration: Oral gavage twice daily for 2 days
    Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
    Decreased the fraction of the vessel cross section occupied by thrombosis.
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Kinase, Natto fermentation]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL; Clear solution; Need ultrasonic

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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    Kinase, Natto fermentation Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Kinase, Natto fermentation133876-92-3PAI-1Plasminogen activator inhibitor-1fibrinolyticenzymeclotshydrolyzingfibrinplasmincardiovascularthrombosisInhibitorinhibitorinhibit

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