Kinase, Natto fermentation
Based on 4 publication(s) in Google Scholar
Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 133876-92-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Kinase, Natto fermentation
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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WB
Biological Activity
Kinase, Natto fermentation dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2].
Product Information
Molecular weight: 27728 Da (a single-chain polypeptide enzyme composed of 275 amino acids in a fixed arrangement)
Acidity and alkalinity: relatively stable in neutral or alkaline environment (pH 7.0 ~12.0), extremely unstable when pH <5.0. However, the stability of nattokinase is greatly improved after mixing with boiled rice extract, broth, serum protein and gastric juice protein, and the enzyme activity will not be completely lost even under acidic conditions.
Temperature: sensitive to high temperature, with better stability below 37°C, and it will be quickly inactivated due to protein denaturation when the temperature is higher than 60°C. Freeze-thaw: After repeated freeze-thaw cycles for 5 times, 95% of the original activity can still be retained.
Instructions
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3]
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Dosage:150, 250 mg/kg
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Administration:Oral gavage twice daily for 2 days
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Result:Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
Decreased the fraction of the vessel cross section occupied by thrombosis.
Chemical Information
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CAS No. 133876-92-3
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Appearance Solid
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Color White to off-white
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SMILES
[Kinase, Natto fermentation]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Adv Healthc Mater
An Injectable Clinical-Grade Fibrin Hydrogel Restores Fertility in Intrauterine Adhesions via MSC-Mediated Immune and Regenerative Modulation, Unlocking an Equivalent Cell-Free EV-Based Therapy. [Abstract]2026 Apr;15(15):e04360. PMID: 41660804 -
BMC Biol
2023 Dec 10;21(1):290. PMID: 38072992 -
Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.
Cells were exposed to different concentrations of nattokinase for various durations, after which cell viability was measured.
Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.
Cells were pretreated with Kinase, Natto fermentation for 1 hour, then exposed to PM, and then (B) COX-2 protein expression was detected.
Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.
Cells were pretreated with NAC, APO, DPI, or natto kinase (Natto fermentation) for 1 hour, then exposed to PM, and Akt phosphorylation was detected.
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Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523. [Content Brief]
[2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567. [Content Brief]
[3]. Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kinase, Natto fermentation Related Classifications
HY-P2373 Related Classifications
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