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  4. Nattokinase, Natto fermentation

Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.

For research use only. We do not sell to patients.

Nattokinase, Natto fermentation Chemical Structure

Nattokinase, Natto fermentation Chemical Structure

CAS No. : 133876-92-3

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Nattokinase, Natto fermentation Related Antibodies

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Description

Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].

In Vitro

Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nattokinase, Natto fermentation Related Antibodies
In Vivo

Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3]
Dosage: 150, 250 mg/kg
Administration: Oral gavage twice daily for 2 days
Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
Decreased the fraction of the vessel cross section occupied by thrombosis.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Nattokinase, Natto fermentation]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (Infinity mM); Clear solution; Need ultrasonic

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nattokinase, Natto fermentation133876-92-3OthersfibrinolyticenzymeclotshydrolyzingfibrinplasmincardiovascularthrombosisInhibitorinhibitorinhibit

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