2. Biochemical Assay Reagents
  3. Nattokinase

Nattokinase 

Cat. No.: HY-P2373
COA Handling Instructions

Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.

For research use only. We do not sell to patients.

Nattokinase Chemical Structure

Nattokinase Chemical Structure

CAS No. : 133876-92-3

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Based on 1 publication(s) in Google Scholar

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Description

Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].

In Vitro

Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3]
Dosage: 150, 250 mg/kg
Administration: Oral gavage twice daily for 2 days
Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
Decreased the fraction of the vessel cross section occupied by thrombosis.
Clinical Trial
Appearance

Solid

CAS No.
SMILES

[Nattokinase]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (Infinity mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Nattokinase133876-92-3OthersfibrinolyticenzymeclotshydrolyzingfibrinplasmincardiovascularthrombosisInhibitorinhibitorinhibit

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