Nialamide hydrochloride
Nialamide hydrochloride is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide hydrochloride inhibits MAO and regulates ROS production. Nialamide hydrochloride induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide hydrochloride can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension.
For research use only. We do not sell to patients.
- CAS No.: 1161-03-1
- Formula: C16H19ClN4O2
- Molecular Weight:334.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nialamide (10 μM) hydrochloride decreases ROS levels in NMDA (HY-17551)- and Kainic acid (HY-N2309)- stimulated rat cerebellar granule cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nialamide (1-10 mg/kg; i.v.) hydrochloride potentiates Noradrenaline's pressor effect in Reserpine (HY-N0480)-pretreated pithed cats[4].
Nialamide (100 mg/kg; i.p.) hydrochloride enhances the anticonvulsant effect of Diphenylhydantoin in mice[5].
Nialamide (200 mg/kg; i.p.) hydrochloride induces increased motor activity, rectal temperature, and elevated brain 5-HT, NA, and dopamine levels in mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1161-03-1
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Molecular Weight 334.80
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Formula C16H19ClN4O2
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SMILES
O=C(C1=CC=NC=C1)NNCCC(NCC2=CC=CC=C2)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Boldyrev AA, et al. Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells. Biochem Biophys Res Commun. 1999 Mar 16;256(2):320-4. [Content Brief]
[2]. Lee H, et al. Ionizing radiation induced modification of nialamide as an anti inflammatory agent against lipopolysaccharide induced RAW 264.7 and DH82 cells. Exp Ther Med. 2024 Mar 11;27(5):192. [Content Brief]
[3]. Buus Lassen J. Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium. Psychopharmacology (Berl). 1989;98(2):257-61. [Content Brief]
[4]. DAVEY MJ, et al. The effects of nialamide on adrenergic functions. Br J Pharmacol Chemother. 1963 Feb;20(1):121-34. [Content Brief]
[5]. P'AN SY, et al. Anticonvulsant effect of nialamide and diphenylhydantoin. Proc Soc Exp Biol Med. 1961 Dec;108:680-3. [Content Brief]
[6]. Modigh K, et al. On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome. Br J Pharmacol. 1972 Sep;46(1):32-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nialamide hydrochloride Related Classifications
HY-B1199A Related Classifications
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