AAA
Based on 1 publication(s) in Google Scholar
AAA is an orally active 20-HETE receptor antagonist. AAA exerts antihypertensive and organoprotective effects. AAA blocks 20-HETE prohypertensive actions, suppresses intrarenal and circulating angiotensin II levels, and interferes with renin-angiotensin system interactions. AAA attenuates development of, and reverses established, ANG II (HY-13948)-dependent malignant hypertension. AAA reduces albuminuria, glomerulosclerosis, and cardiac hypertrophy linked to malignant hypertension. AAA can be used for the research of malignant hypertension.
For research use only. We do not sell to patients.
- Purity: 99.52%
- Formula: C24H39NNa2O6
- Molecular Weight:483.55
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AAA
MoreAll Angiotensin Receptor Isoforms
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Biological Activity
AAA (10 mg/kg; p.o.; in water; daily; 3 days) rapidly restores impaired renal hemodynamics and vascular responsiveness in Cyp1a1-Ren-2 transgenic rats with established malignant hypertension[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cyp1a1-Ren-2 transgenic (male; malignant hypertension model induced by 0.3% indole-3-carbinol dietary administration)[1]
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Dosage:10 mg/kg per day
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Administration:P.o.; daily; 12 days
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Result:Reduced SBP elevation to 161 ± 3 mmHg (vs. 199 ± 3 mmHg in untreated I3C-induced rats).
Attenuated albuminuria, glomerulosclerosis index, and cardiac hypertrophy.
Lowered elevated kidney ANG II levels from 405 ± 14 fmol/g to 72 ± 6 fmol/g.
Prevented body weight loss, hunched posture, piloerection, and polydipsia associated with untreated malignant hypertension.
Chemical Information
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Appearance Solid
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Molecular Weight 483.55
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Formula C24H39NNa2O6
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Color White to off-white
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SMILES
O=C([C@@H](NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Tissue Cell
Antagonism of GPR75 inhibits gestational diabetes mellitus-induced placental tissue injury by preventing activation of the NLRP3 inflammasome. [Abstract]2026 Aug:101:103515. PMID: 41962334
Solvent & Solubility
H2O : ≥ 100 mg/mL (206.80 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 1 mg/mL (2.07 mM); Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0680 mL | 10.3402 mL | 20.6804 mL | 51.7010 mL |
| 5 mM | 0.4136 mL | 2.0680 mL | 4.1361 mL | 10.3402 mL | |
| 10 mM | 0.2068 mL | 1.0340 mL | 2.0680 mL | 5.1701 mL | |
| 15 mM | 0.1379 mL | 0.6893 mL | 1.3787 mL | 3.4467 mL | |
| 20 mM | 0.1034 mL | 0.5170 mL | 1.0340 mL | 2.5850 mL | |
| 25 mM | 0.0827 mL | 0.4136 mL | 0.8272 mL | 2.0680 mL | |
| 30 mM | 0.0689 mL | 0.3447 mL | 0.6893 mL | 1.7234 mL | |
| 40 mM | 0.0517 mL | 0.2585 mL | 0.5170 mL | 1.2925 mL | |
| 50 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0340 mL | |
| 60 mM | 0.0345 mL | 0.1723 mL | 0.3447 mL | 0.8617 mL | |
| 80 mM | 0.0259 mL | 0.1293 mL | 0.2585 mL | 0.6463 mL | |
| 100 mM | 0.0207 mL | 0.1034 mL | 0.2068 mL | 0.5170 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AAA Related Classifications
HY-160187 Related Classifications
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