Supradamal
Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.
For research use only. We do not sell to patients.
- CAS No.: 71458-51-0
- Formula: C17H21N3O2
- Molecular Weight:299.37
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
Description
In Vitro
Supradamal inhibits the growth of Plasmodium falciparum in human red blood cells, including the development of trophozoites[1].
Supradamal (Compound 4a) inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium falciparum FKBD35, with an IC50 of 83 nM[3].
Supradamal inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium vivax FKBD35 with an IC50 of 75 nM[3].
Supradamal (48 h) inhibits the growth of *Plasmodium falciparum* strain 3D7 in vitro by specifically interfering with the development of the trophozoite stage, while exerting no effect on ring-stage parasites[3].
Supradamal (500 nM; 4-16 h) specifically inhibits the development of trophozoite-stage parasites of the Plasmodium falciparum 3D7 strain, with no effect on ring-stage or schizont-stage parasites[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 71458-51-0
-
Appearance Solid
-
Molecular Weight 299.37
-
Formula C17H21N3O2
-
Color White to off-white
-
SMILES
O=C(C1=CC=NC=C1)NNC(C23CC4CC(C3)CC(C2)C4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[2]. Rasch J, et al. Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila. Frontiers in bioengineering and biotechnology. 2015;3:41. [Content Brief]
[3]. Harikishore A, et al. Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS medicinal chemistry letters. 2013 Nov 14;4(11):1097-101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Supradamal Related Classifications
HY-183450 Related Classifications
Powered by Bioz