2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-34

NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis.

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NLRP3-IN-34 Chemical Structure

NLRP3-IN-34 Chemical Structure

CAS No. : 1392502-55-4

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NLRP3-IN-34 Related Antibodies

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Description

NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis[1].

Molecular Weight

430.45

Formula

C26H22O6
CAS No.
SMILES

CC1=COC2=C1C(C(C3=C2C=CC4=C3C(CCC4(C)C)OC(C5=C(C=CC=C5)O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-341392502-55-4NOD-like Receptor (NLR)C57BL/6 miceperitonitisJ774A.1Inhibitorinhibitorinhibit

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