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Cat. No.: HY-170529

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NLRP3-IN-61

NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC₅₀ of 12.6 nM, inhibits IL-β release with an IC₅₀ of 25.3 nM.

For research use only. We do not sell to patients.

CAS No.: 3060585-94-3
Formula: C₂₁H₂₁N₃O₃
Molecular Weight:363.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NLRP3-IN-61 Chemical Structure

CAS No.: 3060585-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC₅₀ of 12.6 nM, inhibits IL-β release with an IC₅₀ of 25.3 nM^[1].

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

CAS No. 3060585-94-3
Molecular Weight 363.41
Formula C₂₁H₂₁N₃O₃
SMILES

OC1=C(CCC2)C2=CC(C)=C1C3=CC=C(OC([C@@H]4CCC(NC4)=O)=N5)C5=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. BOUCHE LA, et al., 5-[5-(2-hydroxyphenyl)oxazolo[4,5-b]pyridin-2-yl]piperidin-2-one derivatives as nlpr3 inhibitors for the treatment of inflammatory diseases. WO2024218188

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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NLRP3-IN-61

All NOD-like Receptor (NLR) Isoforms