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Norswertianolin 

Cat. No.: HY-N6617
Handling Instructions

Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases.

For research use only. We do not sell to patients.

Norswertianolin Chemical Structure

Norswertianolin Chemical Structure

CAS No. : 54954-12-0

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Description

Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2].

IC50 & Target

CSE[2]

In Vitro

Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H2O2-induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells[1]. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (10~12 weeks)[2]
Dosage: 4.4 mg/kg/day
Administration: S.c.
Result: Improved CSE/H2S production.
Molecular Weight

422.34

Formula

C₁₉H₁₈O₁₁

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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