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Cat. No.: HY-122069

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NSC177365

(Synonyms: NSC 1)

NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC₅₀s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent.

For research use only. We do not sell to patients.

CAS No.: 80261-18-3
Formula: C₂₃H₂₃N₇O₄S
Molecular Weight:493.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NSC177365 Chemical Structure

CAS No.: 80261-18-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 80261-18-3
Molecular Weight 493.54
Formula C₂₃H₂₃N₇O₄S
SMILES

O=S(CCCNC(N)=N)(NC1=CC=C(NC2=C(C=CC([N+]([O-])=O)=C3)C3=NC4=CC=CC=C42)C=C1)=O
Synonyms

NSC 1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hernandez I, et al. Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development. ACS Omega. 2025 Apr 9;10(15):15775-15780. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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