Nur77 modulator 2 

Nur77 modulator 2, a Nur77 modulator (K_d of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria^[1].

Nur77 modulator 2 (Compound B7) significantly decreases the production of cytokines in vitro, such as NO, IL-6, IL-1β, and TNF-α, at concentrations of 1.25 μM, 2.5 μM, and 5 μM. Nur77 modulator 2 inhibits the lipopolysaccharides (LPS)-induced inflammation via the blockade of NF-κB activation in a Nur77-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nur77 modulator 2 (Compound B7; 5-10 mg/kg; p.o; for 1 week) shows in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

431.48

C₂₆H₂₅NO₅

2055829-03-1

O=C(NO)C1=CC=C(C2=CC(C3=CC(O)=CC(C4(C5)CC6CC5CC(C6)C4)=C3O2)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645.  [Content Brief]