As-CA11
As-CA11 is a Thioredoxin reductase (TrxR) inhibitor with an IC50 of 18.7 nM. As-CA11 can induce cancer cells apoptosis and ROS production. As-CA11 can reduce the level of reduced Trx and increase the level of oxidized Trx. As-CA11 demonstrates anti-tumor activity in the 4T1 tumor-bearing mouse model.
For research use only. We do not sell to patients.
- Formula: C18H16AsCl2NOS2
- Molecular Weight:472.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
As-CA11 is shows potent inhibitory activities against HeLa, HepG2, A549 and HL-60 cells with IC50 of 0.35, 0.3, 0.43 and 0.28 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 472.28
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Formula C18H16AsCl2NOS2
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SMILES
ClC1=CC=CC(Cl)=C1/C=C/C(NC2=CC=C([As]3SCCCS3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
As-CA11 Related Classifications
HY-179712 Related Classifications
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