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Cat. No.: HY-139846

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MK-4688

MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

For research use only. We do not sell to patients.

CAS No.: 1616428-79-5
Formula: C₂₈H₃₂ClN₇O₃
Molecular Weight:550.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MK-4688 Chemical Structure

CAS No.: 1616428-79-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Hot Topics (2)
Calculators
Help & FAQs
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Biological Activity

Description

MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	122 nM Compound: 56; MK-4688	Antiproliferative activity against human HCT-116 cells expressing wild-type p53 incubated for 72 hrs Antiproliferative activity against human HCT-116 cells expressing wild-type p53 incubated for 72 hrs	[PMID: 34714078]

Chemical Information

CAS No. 1616428-79-5
Molecular Weight 550.05
Formula C₂₈H₃₂ClN₇O₃
SMILES

C[C@@H](CC1)CC[C@H]1CN(C(N2CCO[C@H]3[C@H]2CCC3)=N4)C5=C4C=C(C(N6)=NOC6=O)N=C5C7=CC(Cl)=CN=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Reutershan MH, et al. Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):16213-16241. [Content Brief]

Hot Topics

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Topics Protein-Protein Interaction: Therapeutic Target-Beyond Cancer
Protein-protein interactions (PPIs) constitute the molecular framework that organizes signaling networks, gene regulation, metabolism, immunity, and cellular homeostasis.

2026-06-18
Topics A Review of the Mechanisms and Applications of Protein-Protein Interactions (PPIs)
Protein-protein interactions (PPIs) are physical or functional connections formed by two or more proteins through specific interfaces, and they underlie signal transduction, transcriptional regulation, protein degradation, cell-cycle control, DNA repair, immune recognition, and cell death.

2026-06-18

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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