RGD-4C
Based on 1 Customer Validation
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models.
For research use only. We do not sell to patients.
- Purity : 99.91%
- CAS No.: 332179-76-7
- Formula: C42H60N14O16S4
- Molecular Weight:1145.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
In Vivo
Modified RGD-4C fused with the N-terminus of plant-derived single-chain ribosome inactivating protein saporin (SAP) (called RGD-SAP), (diluted in sodium chloride, 0.9%; i.v.; 200 µL; every 5 days, for 3 times) exerts anti-tumor activity in a model of muscle invasive bladder cancer[3].
RGD-SAP in combination with mitomycin C, a chemotherapeutic drug, increases the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 332179-76-7
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Appearance Solid
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Molecular Weight 1145.27
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Formula C42H60N14O16S4
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Color White to off-white
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Sequence Shortening
ACDCRGDCFCG(Disulfide bridge: Cys2-Cys10; Cys4-Cys8)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (43.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8. [Content Brief]
[2]. Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7. [Content Brief]
[3]. Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8732 mL | 4.3658 mL | 8.7316 mL | 21.8289 mL |
| 5 mM | 0.1746 mL | 0.8732 mL | 1.7463 mL | 4.3658 mL | |
| 10 mM | 0.0873 mL | 0.4366 mL | 0.8732 mL | 2.1829 mL | |
| 15 mM | 0.0582 mL | 0.2911 mL | 0.5821 mL | 1.4553 mL | |
| 20 mM | 0.0437 mL | 0.2183 mL | 0.4366 mL | 1.0914 mL | |
| 25 mM | 0.0349 mL | 0.1746 mL | 0.3493 mL | 0.8732 mL | |
| 30 mM | 0.0291 mL | 0.1455 mL | 0.2911 mL | 0.7276 mL | |
| 40 mM | 0.0218 mL | 0.1091 mL | 0.2183 mL | 0.5457 mL |
RGD-4C Related Classifications
HY-P3732 Related Classifications
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