Oleic Acid-2,6-diisopropylanilide 

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC₅₀ of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.

441.73

C₃₀H₅₁NO

140112-65-8

Liquid

Colorless to light yellow

CC(C1=C(C(C(C)C)=CC=C1)N(C(CCCCCCC/C=C\CCCCCCCC)=O)[H])C

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Roth, et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J. Med. Chem. 35(9), 1609-1617 (1992).