2. Immunology/Inflammation Cytoskeleton Cell Cycle/DNA Damage
  3. FAP Microtubule/Tubulin
  4. OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE  (Synonyms: OncoFAP glidotin)

Cat. No.: HY-175350 Purity: 99.71%
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OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49  nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research.

For research use only. We do not sell to patients.

OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE Chemical Structure

CAS No. : 2688118-55-8

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Based on 1 publication(s) in Google Scholar

OncoFAP-GlyPro-MMAE Related Antibodies

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Description

OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49  nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research[1].

Molecular Weight

2135.38

Formula

C102H141F2N19O27S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC(N1[C@H](C#N)CC(F)(F)C1)=O)C2=CC=NC3=C(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@](CCC7)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C8=CC=CC=C8)O)=O)=O)=O)=O)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)C=CC=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (46.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4683 mL 2.3415 mL 4.6830 mL
5 mM 0.0937 mL 0.4683 mL 0.9366 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4683 mL 2.3415 mL 4.6830 mL 11.7075 mL
5 mM 0.0937 mL 0.4683 mL 0.9366 mL 2.3415 mL
10 mM 0.0468 mL 0.2342 mL 0.4683 mL 1.1708 mL
15 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7805 mL
20 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.5854 mL
25 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
30 mM 0.0156 mL 0.0781 mL 0.1561 mL 0.3903 mL
40 mM 0.0117 mL 0.0585 mL 0.1171 mL 0.2927 mL
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OncoFAP-GlyPro-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OncoFAP-GlyPro-MMAE2688118-55-8OncoFAP glidotinFAPMicrotubule/TubulinFibroblast activation proteinSmall molecule-drug conjugateSMDCTubulinMMAECancersInhibitorinhibitorinhibit

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