Org 25543 hydrochloride (Standard)
Org 25543 hydrochloride (Standard) is the analytical standard of Org 25543 (hydrochloride) (HY-107527). This product is intended for research and analytical applications. Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor (IC50: 16 nM). Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.
For research use only. We do not sell to patients.
- CAS No.: 495076-64-7
- Formula: C24H33ClN2O4
- Molecular Weight:448.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-107527
Org 25543 hydrochlorideGlyT2 Inhibitor -
HY-101037
SarcosineGlyT1 Inhibitor -
HY-10809
Bitopertin -
HY-10711A
ALX-5407 hydrochlorideGlyT1 Inhibitor -
HY-101037R
Sarcosine (Standard)GlyT1 Inhibitor -
HY-138935
IclepertinGlyT1 Inhibitor -
HY-100416A
LY2365109 hydrochlorideGlyT1 Inhibitor -
HY-10716A
PF-03463275GlyT1 Inhibitor -
HY-10809R
Bitopertin (Standard) -
HY-130466
Stearoyl-L-carnitine chlorideEndogenous Metabolite -
HY-110176
ASP2535GlyT1 Inhibitor -
HY-112432
GlyT1 Inhibitor 1
Biological Activity
Description
Chemical Information
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CAS No. 495076-64-7
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Molecular Weight 448.98
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Formula C24H33ClN2O4
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SMILES
COC(C=C(C(NCC1(CCCC1)N(C)C)=O)C=C2OC)=C2OCC3=CC=CC=C3.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Caulfield WL, et al. The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem. 2001 Aug 16;44(17):2679-82. [Content Brief]
[2]. Morita K, et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45. [Content Brief]
[3]. Mohammadzadeh A, et al. Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. Int J Mol Sci. 2021 Mar 1;22(5):2479. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Org 25543 hydrochloride (Standard) Related Classifications
HY-107527R Related Classifications
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