Org 25935
Based on 1 Customer Validation
Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse.
For research use only. We do not sell to patients.
- Purity : 99.3%
- CAS No.: 949588-40-3
- Formula: C21H26ClNO3
- Molecular Weight:375.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-10809
Bitopertin -
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Bitopertin (Standard) -
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ALX-1393GlyT Inhibitor -
HY-100416
LY2365109GlyT1 Inhibitor -
HY-10716A
PF-03463275GlyT1 Inhibitor -
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LY2365109 hydrochlorideGlyT1 Inhibitor -
HY-112432
GlyT1 Inhibitor 1 -
HY-10715
SSR504734GlyT1 Inhibitor -
HY-10809A
Bitopertin (R enantiomer)GlyT Inhibitor -
HY-10716AR
PF-03463275 (Standard)Reference Standard -
HY-100416AR
LY2365109 hydrochloride (Standard)GlyT1 Inhibitor
Biological Activity
Description
IC50 & Target
[1]|
GlyT1 100 nM (IC50) |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 949588-40-3
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Appearance Solid
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Molecular Weight 375.89
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Formula C21H26ClNO3
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Color White to off-white
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SMILES
OC(CN(C)C[C@@H]1[C@H](C2=CC=CC=C2)C3=CC=C(OC)C=C3CC1)=O.Cl
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Synonyms
SCH 900435
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Org 25935 Related Classifications
HY-122666 Related Classifications
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