P-gp inhibitor 13
P-gp inhibitor 13 is a P-gp inhibitor. P-gp inhibitor 13 can reverse P-glycoprotein-mediated paclitaxel resistance in A2780/T cell. P-gp inhibitor 13 can be used for the research of advanced acute myeloid leukemia.
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- CAS 番号: 3041121-57-4
- 分子式: C32H34O8
- 分子量:546.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780/Taxol | IC50 |
0.01 μM
Compound: 27f
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Reversal of multi-drug resistance in human A2780/Taxol cells incubated for 48 hrs by MTT assay
Reversal of multi-drug resistance in human A2780/Taxol cells incubated for 48 hrs by MTT assay
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[PMID: 36871374] |
体外実験
P-gp inhibitor 13 (Compound 27f) shows a remarkable chemo-sensitization in A2780/T cells with an IC50 value of 0.010 μM[1].
P-gp inhibitor 13 is effective to increase the accumulation of paclitaxel and Rhodamine 123 via inhibiting P-gp for reversing multidrug-resistance[1].
P-gp inhibitor 13 hardly has relevant cardiac toxicity[1].
P-gp inhibitor 13 (2.5 μM, 5 μM, 10 μM, 20 μM) demonstrates concentration-dependent MDR reversal activities in A2780/T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3041121-57-4
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分子量 546.61
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分子式 C32H34O8
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SMILES
COC1=CC(CC(OCC2=C3OC(C(CC4=CC=CC=C4)=C(C3=CC=C2OC(C)C)C)=O)=O)=CC(OC)=C1OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
P-gp inhibitor 13 関連分類
HY-149981 関連分類
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