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Cat. No.: HY-149981

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P-gp inhibitor 13

P-gp inhibitor 13 is a P-gp inhibitor. P-gp inhibitor 13 can reverse P-glycoprotein-mediated paclitaxel resistance in A2780/T cell. P-gp inhibitor 13 can be used for the research of advanced acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 3041121-57-4
Formula: C₃₂H₃₄O₈
Molecular Weight:546.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

P-gp inhibitor 13 Chemical Structure

CAS No.: 3041121-57-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780/Taxol	IC₅₀	0.01 μM Compound: 27f	Reversal of multi-drug resistance in human A2780/Taxol cells incubated for 48 hrs by MTT assay Reversal of multi-drug resistance in human A2780/Taxol cells incubated for 48 hrs by MTT assay	[PMID: 36871374]

In Vitro

P-gp inhibitor 13 (Compound 27f) shows a remarkable chemo-sensitization in A2780/T cells with an IC₅₀ value of 0.010 μM^[1].
P-gp inhibitor 13 is effective to increase the accumulation of paclitaxel and Rhodamine 123 via inhibiting P-gp for reversing multidrug-resistance^[1].
P-gp inhibitor 13 hardly has relevant cardiac toxicity^[1].
P-gp inhibitor 13 (2.5 μM, 5 μM, 10 μM, 20 μM) demonstrates concentration-dependent MDR reversal activities in A2780/T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3041121-57-4
Molecular Weight 546.61
Formula C₃₂H₃₄O₈
SMILES

COC1=CC(CC(OCC2=C3OC(C(CC4=CC=CC=C4)=C(C3=CC=C2OC(C)C)C)=O)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang W, et al. Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells. Eur J Med Chem. 2023;250:115218. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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