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Cat. No.: HY-162447

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P-gp inhibitor 22

P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase.

For research use only. We do not sell to patients.

CAS No.: 1226674-74-3
Formula: C₂₀H₁₃ClN₂O₂
Molecular Weight:348.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

P-gp inhibitor 22 Chemical Structure

CAS No.: 1226674-74-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

P-gp inhibitor 22 (compound 4b; 6.25-100 μM; 24 h) demonstrates significant vigour against MCF-7/ADR cells^[1].
P-gp inhibitor 22 (compound 4b; 5 μM; 24 h) induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase^[1].
P-gp inhibitor 22 inhibits a variety cell lines, such as PC-3, SKOV-3, HeLa, MCF-7/ADR, HFL-1, and WI-38 cells, the IC₅₀ values of 3.3 μM, 0.7 μM, 2.4 μM, 5.0 μM, 72.0 μM, and 61.1 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7/ADR cells
Concentration:

6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time:

24 h
Result:

Showed dose-dependent cytotoxicity in MCF-7/ADR cells.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7/ADR cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Showed cell cycle arrest at S phase and induced apoptosis.

Chemical Information

CAS No. 1226674-74-3
Molecular Weight 348.78
Formula C₂₀H₁₃ClN₂O₂
SMILES

N#CC1=C(N)OC2=C(C3=CC(O)=CC=C3C=C2)C1C4=CC=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ashraf H F Abd El-Wahab, et al. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Sci Rep. 2024 Mar 31;14(1):7589. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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