P-gp modulator-5

Cat. No.: HY-162822: Data Sheet Handling Instructions
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P-gp modulator-5 (compound 25) is a modulator of P-gp and can inhibit the proliferation of multidrug resistant (MDR) tumors. P-gp modulator-5 inhibits the activity of drug efflux pumps in MDR cells, leading to a large accumulation of ROS and altered cell cycle profiles.

For research use only. We do not sell to patients.

P-gp modulator-5 Chemical Structure

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.22 μM Compound: 25	Inhibition of human A549 cells incubated for 48 hrs by SRB method Inhibition of human A549 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
COLO 205	GI₅₀	0.16 μM Compound: 25	Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
DLD-1	GI₅₀	0.61 μM Compound: 25	Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
H322	GI₅₀	0.174 μM Compound: 25	Inhibition of human H322 cells incubated for 48 hrs by SRB method Inhibition of human H322 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
K562	GI₅₀	0.25 μM Compound: 25	Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
LOX IMVI	GI₅₀	0.19 μM Compound: 25	Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method	[PMID: 39093920]
MCF7	GI₅₀	0.15 μM Compound: 25	Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
MRC5	GI₅₀	1.53 μM Compound: 25	Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
NCI-H460	GI₅₀	0.35 μM Compound: 25	Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
NCI/ADR-RES	GI₅₀	0.23 μM Compound: 25	Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method	[PMID: 39093920]
OVCAR-3	GI₅₀	0.048 μM Compound: 25	Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
OVCAR-8	GI₅₀	0.24 μM Compound: 25	Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
UACC-62	GI₅₀	0.16 μM Compound: 25	Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method	[PMID: 39093920]

Molecular Weight

352.34

Formula

C₁₉H₁₆N₂O₅

SMILES

O=C1C=C(C(C2=C(C(C)=[N+](C=C21)[O-])C(OC)=O)=O)NCC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Discovery of Potent Isoquinolinequinone N-Oxides to Overcome Cancer Multidrug Resistance

P-gp modulator-5 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp modulator-5P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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P-gp modulator-5

P-gp modulator-5 Related Antibodies

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P-gp modulator-5 Related Classifications

Molarity Calculator

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