P2Y14R antagonist 3
P2Y14R antagonist 3 (Compound A) is a potent and orally active P2Y14R antagonist with an IC50 value of 23.60 nM and a Kd value of 7.26 μM. P2Y14R antagonist 3 can reduce the degree of lung injury in the Lipopolysaccharides (LPS) (HY-D1056)-induced acute lung injury mice. P2Y14R antagonist 3 can be used for inflammatory diseases.
For research use only. We do not sell to patients.
- Formula: C26H25N5O5
- Molecular Weight:487.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2Y Receptor Isoforms
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Biological Activity
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P2Y14 Receptor 23.6 nM (IC50) |
P2Y14 Receptor 7.26 μM (Kd) |
P2Y14R antagonist 3 exhibits no inhibitory effect on CYP1A2 and CYP2C9, and weak inhibitory activity against CYP2C19 and CYP3A4, with IC50 values of 28.6 μM and 21.3 μM, respectively[1].
P2Y14R antagonist 3 does not exhibits cardiotoxic side effects, exhibits exceptional biopharmaceutical stability, demonstrating resistance to degradation in simulated gastric fluid and intestinal fluid, maintaining high metabolic stability in human liver microsomes, classify it as a low-clearance compound[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced acute lung injury male C57BL/6 mice (6-8 weeks)[1]
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Dosage:2 mg/kg, 6 mg/kg
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Administration:Oral gavage (p.o.); once daily for 7 days, on the 5th day of the experiment, mice were injected with 25 mg/kg LPS to induce Acute Lung Injury (ALI), and mice were killed 3 h after 7th day administration.
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Result:Reduced inflammation and reduced tissue damage, and reduced the content of inflammatory cytokines and the pathological changes of lung tissue in LPS-induced ALI mouse model.
Chemical Information
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Molecular Weight 487.51
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Formula C26H25N5O5
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SMILES
CNC(C1CN(CC12CCN(CC2)C(C3=NOC4=CC=CC=C43)=O)C(C5=C6C=CC=CC6=NO5)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P2Y14R antagonist 3 Related Classifications
HY-172226 Related Classifications
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