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Cat. No.: HY-179448

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P2Y2R antagonist 1

P2Y2R antagonist 1 is a selective P2Y2R antagonist (pIC₅₀ = 7.78). P2Y2R antagonist 1 can be used for the study of Glioma.

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CAS No.: 3120348-70-8
화학식: C₃₈H₃₄N₄O₄S
분자량:642.77

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

P2Y2R antagonist 1 Chemical Structure

CAS No.: 3120348-70-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

P2Y2R antagonist 1 is a selective P2Y2R antagonist (pIC₅₀ = 7.78). P2Y2R antagonist 1 can be used for the study of Glioma^[1].

All P2Y Receptor Isoforms :

In Vitro

P2Y2R antagonist 1 (Compound 32g) shows no activity against hP2Y1, hP2Y4, and hP2Y11 receptors in 1321N1 cells (pIC₅₀ < 5), and exhibited 0% inhibition against P2Y11 at a concentration of 10 μM^[1].
P2Y2R antagonist 1 has a LogD_7.4 value of 4.57, indicating high lipophilicity^[1].
P2Y2R antagonist 1 (0.1-10 μM, 1-72 h) at a concentration of 10 μM shows significant cytotoxicity against 1321N1 cells, with the maximum effect occurring 48 hours, while CHO cells show low sensitivity to the P2Y2R antagonist^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Cytotoxicity Assay^[1]

View Protocol

Cell Line:

Native 1321N1 cells, CHO cells
Concentration:

0.1 μM, 1 μM, 10 μM
Incubation Time:

1 h, 24 h, 48 h, 72 h
Result:

At a concentration of 10 μM, the compound showed significant cytotoxicity against 1321N1 cells, with the maximum effect occurring 48 hours after treatment. In contrast, CHO cells showed low sensitivity to the P2Y2R antagonist.

Chemical Information

CAS No. 3120348-70-8
분자량 642.77
화학식 C₃₈H₃₄N₄O₄S
SMILES

O=C(C1=CC=C(CN(C(N2)=O)C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C35)C2=S)O1)NC6=CC7=C(N(CC)C(CC7)=O)C=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abdalrahman RAM, et al. From tetrazole to isoquinolinone: Structure-based optimization and late-stage diversification of AR-C118925-derived P2Y2 receptor antagonists. Eur J Med Chem. 2026 Jan 15;302(Pt 2):118335. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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