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Cat. No.: HY-179448

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P2Y2R antagonist 1

P2Y2R antagonist 1 is a selective P2Y2R antagonist (pIC₅₀ = 7.78). P2Y2R antagonist 1 can be used for the study of Glioma.

For research use only. We do not sell to patients.

CAS No.: 3120348-70-8
Formula: C₃₈H₃₄N₄O₄S
Molecular Weight:642.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

P2Y2R antagonist 1 Chemical Structure

CAS No.: 3120348-70-8

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

P2Y2R antagonist 1 is a selective P2Y2R antagonist (pIC₅₀ = 7.78). P2Y2R antagonist 1 can be used for the study of Glioma^[1].

All P2Y Receptor Isoforms :

In Vitro

P2Y2R antagonist 1 (Compound 32g) shows no activity against hP2Y1, hP2Y4, and hP2Y11 receptors in 1321N1 cells (pIC₅₀ < 5), and exhibited 0% inhibition against P2Y11 at a concentration of 10 μM^[1].
P2Y2R antagonist 1 has a LogD_7.4 value of 4.57, indicating high lipophilicity^[1].
P2Y2R antagonist 1 (0.1-10 μM, 1-72 h) at a concentration of 10 μM shows significant cytotoxicity against 1321N1 cells, with the maximum effect occurring 48 hours, while CHO cells show low sensitivity to the P2Y2R antagonist^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Native 1321N1 cells, CHO cells
Concentration:

0.1 μM, 1 μM, 10 μM
Incubation Time:

1 h, 24 h, 48 h, 72 h
Result:

At a concentration of 10 μM, the compound showed significant cytotoxicity against 1321N1 cells, with the maximum effect occurring 48 hours after treatment. In contrast, CHO cells showed low sensitivity to the P2Y2R antagonist.

Chemical Information

CAS No. 3120348-70-8
Molecular Weight 642.77
Formula C₃₈H₃₄N₄O₄S
SMILES

O=C(C1=CC=C(CN(C(N2)=O)C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C35)C2=S)O1)NC6=CC7=C(N(CC)C(CC7)=O)C=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abdalrahman RAM, et al. From tetrazole to isoquinolinone: Structure-based optimization and late-stage diversification of AR-C118925-derived P2Y2 receptor antagonists. Eur J Med Chem. 2026 Jan 15;302(Pt 2):118335. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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P2Y2R antagonist 1

All P2Y Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P2Y2R antagonist 1 Related Classifications

HY-179448 Related Classifications