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Cat. No.: HY-171300

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p38α inhibitor 8

p38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC₅₀ of 0.21 µM and 0.202 µM^[1]>.

For research use only. We do not sell to patients.

CAS No.: 1572047-63-2
Formula: C₁₇H₁₃FN₆
Molecular Weight:320.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

p38α inhibitor 8 Chemical Structure

CAS No.: 1572047-63-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

p38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC₅₀ of 0.21 µM and 0.202 µM^[1]>.

IC₅₀ & Target

CK1γ2

0.202 μM (IC₅₀)

p38α

0.21 μM (IC₅₀)

All p38 MAPK Isoforms :

All Casein Kinase Isoforms :

Chemical Information

CAS No. 1572047-63-2
Molecular Weight 320.32
Formula C₁₇H₁₃FN₆
SMILES

FC1=CC=C(C2=C(C3=CC=NC=C3)N(C)C(C4=CN=NN4)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Seerden JP, et al., Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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p38α inhibitor 8

All p38 MAPK Isoforms

All Casein Kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

p38α inhibitor 8 Related Classifications

HY-171300 Related Classifications