PDE1-IN-6
PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells.
For research use only. We do not sell to patients.
- CAS No.: 2877017-16-6
- Formula: C24H26F2N6O
- Molecular Weight:452.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PDE1-IN-6 (compound 6c) (10 and 20 μM, 48 h) induces the apoptosis of U937 and ML-1 cells[1].
PDE1-IN-6 (10 and 20 μM, 48 h) decreases the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increases their cleaved caspase-3, 7, 9 in U937 and ML-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U937 and ML-1 cells
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Concentration:10, 20 μM
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Incubation Time:48 h
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Result:Induced the apoptosis of U937 and ML-1 cells.
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Cell Line:U937 and ML-1 cells
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Concentration:10, 20 μM
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Incubation Time:48 h
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Result:Decreased the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increased their cleaved caspase-3, 7, 9.
Chemical Information
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CAS No. 2877017-16-6
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Molecular Weight 452.50
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Formula C24H26F2N6O
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SMILES
CC(C)(N1N=CC2=C1N=C(N(C2=O)CC3=CC=CC(F)=C3)NCCNC4=CC=C(C=C4)F)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE1-IN-6 Related Classifications
HY-163406 Related Classifications
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