2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphodiesterase (PDE) TNF Receptor
  4. PDE4-IN-10

PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro.

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PDE4-IN-10

PDE4-IN-10 화학구조

CAS No. : 2413564-66-4

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PDE4-IN-10 Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • 순도&문서

  • References

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제품 설명

PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].

IC50 & Target

PDE4B

7.01 ± 1.0 μM (IC50)

PDE4D

 

In Vitro

PDE4-IN-10 (compound 7a) shows 64.56% inhibition at 10 µM against PDE4B, 54% inhibition at 30 µM but 17% inhibition at 10 µM against PDE4D, indicating its selectivity (~3.8 fold) towards PDE4B over PDE4D[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE4-IN-10 Related Antibodies
분자량

243.30

화학식

C18H13N
CAS No.
SMILES

CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PDE4-IN-10 Related Classifications

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  • 농도 희석 계산기

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4-IN-102413564-66-4Phosphodiesterase (PDE)TNF ReceptorTumor Necrosis Factor ReceptorTNFRIsocoumarinBenzo[c]phenanthridinePd-catalystFeCl3PDE4Inhibitorinhibitorinhibit

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상품명:
PDE4-IN-10
Cat. No.:
HY-147950
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