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Cat. No.: HY-N21630

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Phanginin F

Phanginin F is a cassane-type furanoditerpenoid anticancer agent. Phanginin F can be isolated from the seeds of Caesalpinia sappan Linn. Phanginin F exhibits anticancer activity against ovarian cancer, gastric cancer, and non-small cell lung cancer. Phanginin F can be used in research on ovarian cancer, gastric cancer, and non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 1860819-33-5
Formula: C₂₁H₂₈O₆
Molecular Weight:376.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phanginin F Chemical Structure

CAS No.: 1860819-33-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Phanginin F (20 µM; 48 h) shows weak cytotoxicity against human ovarian cancer A2780, ovarian cancer HEY, gastric cancer AGS, and non-small cell lung cancer A549 cells, with viabilities ranging from approximately 64% to 74% after 48 h treatment at 20 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human ovarian cancer A2780, ovarian cancer HEY, gastric cancer AGS, non-small cell lung cancer A549
Concentration:

20 µM
Incubation Time:

48 h
Result:

Reduced cell viability to 64.4% in A2780 cells.
Reduced cell viability to 74.1% in HEY cells.
Reduced cell viability to 71.1% in AGS cells.
Reduced cell viability to 72.8% in A549 cells.
Exhibited weak cytotoxic activity against all four tested cancer cell lines at 20 µM.

Chemical Information

CAS No. 1860819-33-5
Molecular Weight 376.44
Formula C₂₁H₂₈O₆
SMILES

O[C@@H]1[C@@]23[C@](CC[C@]4([H])[C@]3([H])[C@H](C5=C(C=CO5)[C@@H]4C)O)([H])[C@@](CO1)(CCC2)C(OC)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bao H, et al. Cytotoxic and Pro-Apoptotic Effects of Cassane Diterpenoids from the Seeds of Caesalpinia sappan in Cancer Cells. Molecules (Basel, Switzerland). 2016 Jun 18;21(6):791.

[2]. Yodsaoue O, et al. Phanginin A-K, diterpenoids from the seeds of Caesalpinia sappan Linn. Phytochemistry. 2008 Mar;69(5):1242-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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