PHD-IN-3
PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease.
For research use only. We do not sell to patients.
- CAS No.: 2924181-77-9
- Formula: C20H18N6O3
- Molecular Weight:390.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | EC50 |
5 μM
Compound: 15
|
Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
|
[PMID: 38189253] |
| Hep 3B2 | EC50 |
6.8 μM
Compound: 15
|
Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA
Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA
|
[PMID: 38189253] |
| Hep 3B2 | EC50 |
9 μM
Compound: 15
|
Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
|
[PMID: 38189253] |
| Hep 3B2 | IC50 |
>100 μM
Compound: 15
|
Cytotoxicity against human Hep3B cells by CellTiter-Glo assay
Cytotoxicity against human Hep3B cells by CellTiter-Glo assay
|
[PMID: 38189253] |
Chemical Information
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CAS No. 2924181-77-9
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Molecular Weight 390.40
-
Formula C20H18N6O3
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SMILES
O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)