PI3Kα-IN-21
PI3Kα-IN-21 (compound 8) is a PI3Kα inhibitor, and its selectivity for PI3Kα is 10.41/16.99/37.53 times higher than PI3Kβ/γ/δ respectively (IC50: 96.89/568.24/397.48 nM ). PI3Kα-IN-21 inhibits cancer cell activity, proliferation, and migration, and induces mitochondrial apoptosis through the PI3K/Akt/mTOR pathway. PI3Kα-IN-21 exhibits in vivo antitumor potency in a mouse model of non-small cell lung cancer.
For research use only. We do not sell to patients.
- Formula: C38H30N4O
- Molecular Weight:558.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 56 nM (PI3Kα), 96.89 nM (PI3Kβ), 568.24 nM (PI3Kγ), 397.48 nM nM (PI3Kδ)[1]
Chemical Information
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Molecular Weight 558.67
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Formula C38H30N4O
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SMILES
CC1=NC2=C(C(N(C3=CC=C4C(/C(C(N4CC5=CC=CC=C5)=O)=C/C6=CC=CC=C6)=C3)CC7=CC=CC=C7)=N1)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kα-IN-21 Related Classifications
HY-158029 Related Classifications
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