PI3Kα-IN-23
PI3Kα-IN-23 (Compound 9) is an inhibitor of PI3Ka H1047R.
For research use only. We do not sell to patients.
- CAS No.: 3033941-92-0
- Formula: C28H27N3O3
- Molecular Weight:453.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα-H1047R |
PI3Kα-IN-23 inhibits pAKT phosphorylation in cell with IC50=1 nM-500 nM (T-47D); >15 μΜ (SKBR3) ,respectively[1].
PI3Kα-IN-23 can inhibit cell proliferation with EC50=500 nM-2 μΜ (T-47D); 2 μΜ-15 μΜ (SKBR3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in PK-Mouse[1]
| Route | Dose (mg/kg) | Cl (mL/min/kg) | AUClast (h·ng/mL) | F (%) |
| i.v. | 1 | 35.7 | 464 | / |
| p.o. | 10 | / | 1950 | 41 |
IV Vehicle: 20% PEG400 / 20% PG / 60% of 20% ΗΡβCD solution in water
PO Vehicle: 30% SBE3CD in water
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033941-92-0
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Molecular Weight 453.53
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Formula C28H27N3O3
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SMILES
CC1=CC2=C(N=C(C3CC4=C(C=CC=C4)C3)N(C)C2=O)C(C(C)NC5=CC=CC=C5C(O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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