PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29) is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI).
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- No. CAS: 3038119-14-8
- Fòrmula: C26H20ClFN8O
- Peso molecular:514.94
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
0.8 nM (PI3Kδ)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage | IC50 |
1.46 μM
Compound: (S)-29
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Antiinflammatory activity against LPS-stimulated mouse primary peritoneal macrophage assessed as reduction in IL-6 level pretreated with compound for 22 hrs followed by LPS-induction and measured after 2 hrs by ELISA analysis
Antiinflammatory activity against LPS-stimulated mouse primary peritoneal macrophage assessed as reduction in IL-6 level pretreated with compound for 22 hrs followed by LPS-induction and measured after 2 hrs by ELISA analysis
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[PMID: 37606563] |
| Peritoneal macrophage | IC50 |
3.27 μM
Compound: (S)-29
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Antiinflammatory activity against LPS-stimulated mouse primary peritoneal macrophage assessed as reduction in TNF-alpha level pretreated with compound for 22 hrs followed by LPS-induction and measured after 2 hrs by ELISA analysis
Antiinflammatory activity against LPS-stimulated mouse primary peritoneal macrophage assessed as reduction in TNF-alpha level pretreated with compound for 22 hrs followed by LPS-induction and measured after 2 hrs by ELISA analysis
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[PMID: 37606563] |
Chemical Information
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No. CAS 3038119-14-8
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Peso molecular 514.94
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Fòrmula C26H20ClFN8O
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SMILES
ClC1=CC=C2C(N(N=C2[C@@H](N3C4=C(C(C5=CC(F)=C(C=C5)OC)=N3)C(N)=NC=N4)C)C6=CC=CN=C6)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kδ-IN-14 Related Classifications
HY-155975 Related Classifications
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