PI3Kδ-IN-20
PI3Kδ-IN-20 (compound (S)-36) is a potent inhibitor of PI3Kδ, with the IC50 of 6.4 nM. PI3Kδ-IN-20 has oral bioactivity. PI3Kδ-IN-20 shows significant suppression of cell proliferation and remarkable induction of apoptosis both in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 3038178-85-4
- Formula: C20H17ClN8
- Molecular Weight:404.86
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PI3Kδ 6.4 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
0.23 μM
Compound: (S)-36
|
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 48 to 72 hrs by MTT assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 48 to 72 hrs by MTT assay
|
[PMID: 38577724] |
| MV4-11 | IC50 |
0.74 μM
Compound: (S)-36
|
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 48 to 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 48 to 72 hrs by MTT assay
|
[PMID: 38577724] |
Chemical Information
-
CAS No. 3038178-85-4
-
Molecular Weight 404.86
-
Formula C20H17ClN8
-
SMILES
CC1=NN([C@H](C2=NN(C3=CC(Cl)=CC=C23)C4=CC=NC=C4)C)C5=C1C(N)=NC=N5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz