Pizotifen (Standard)
Pizotifen (Standard) (Pizotyline (Standard)) is the analytical standard of Pizotifen (HY-B0115). This product is intended for research and analytical applications. Pizotifen (Pizotyline) is a 5-HT2 receptor antagonist. Pizotifen inhibits the Wnt/β-catenin-EMT signaling pathway and induces mitochondria-mediated Apoptosis. Pizotifen causes transient ERK1/2 phosphorylation and restores ATP. Pizotifen blocks Serotonin (HY-B1473A)-mediated platelet activation, inhibits Serotonin-enhanced ADP-induced platelet aggregation, and prolongs carotid artery occlusion and tail bleeding time. Pizotifen exhibits anticancer activity against gastric cancer and colon cancer. Pizotifen exerts neuroprotective effects in the striatum of R6/2 mice. Pizotifen can be used for research on gastric cancer, colon cancer, Huntington's disease, metastasis, and thromboembolic diseases.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 15574-96-6
- Formula: C19H21NS
- Molecular Weight:295.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-B0115
Pizotifen5-HT2R Antagonist -
HY-14940
Volinanserin5-HT2 Receptor Antagonist -
HY-10562
Ketanserin -
HY-B0352
MirtazapineNaSSA Agent -
HY-15370A
SB-269970 hydrochloride5-HT7 Receptor Antagonist -
HY-19733
Lumateperone tosylate5-HT2A Receptor Antagonist -
HY-17407
Ziprasidone hydrochloride monohydrate5-HT/DA Receptor Antagonist -
HY-B0352R
Mirtazapine (Standard) -
HY-B0731
Perospirone hydrochlorideAntipsychotic Agent -
HY-B1737
Pirenperone5-HT2 Serotonin Receptor Antagonist -
HY-B0115A
Pizotifen malate5-HT2R Antagonist -
HY-10562R
Ketanserin (Standard)5-HT2A Receptor Antagonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 15574-96-6
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Molecular Weight 295.44
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Formula C19H21NS
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SMILES
CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4
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Synonyms
Pizotyline (Standard); BC-105 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jiang Y, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Experimental and therapeutic medicine. 2020 Feb;19(2):817-824. [Content Brief]
[5]. Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PloS one. 2014;9(1):e87026. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pizotifen (Standard) Related Classifications
HY-B0115R Related Classifications
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Keywords
- Pizotifen (Standard)
- 15574-96-6
- Pizotyline (Standard)
- BC-105 (Standard)
- Reference Standards
- 5-HT Receptor
- Wnt
- β-catenin
- Apoptosis
- ERK
- ATP Synthase
- Mitochondrial Metabolism
- ERK1/2 phosphorylation
- Huntington's disease
- Wnt/β-catenin-EMT signaling
- colon cancer
- gastric cancer
- metastasis
- mitochondrial-mediated apoptosis
- platelet activation
- serotonin 5-HT2A/HTR2C receptor
- thromboembolic disorders
- Inhibitor
- inhibitor
- inhibit