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Cat. No.: HY-155290

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PonatiLink-1-24

PonatiLink-1-24 is an Abelson murine leukemia (ABL) enzyme inhibitor.

For research use only. We do not sell to patients.

CAS No.: 2941512-45-2
Formula: C₁₀₁H₁₄₄ClF₅N₁₂O₂₉
Molecular Weight:2120.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

PonatiLink-1-24 Chemical Structure

CAS No.: 2941512-45-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PonatiLink-1-24 is an Abelson murine leukemia (ABL) enzyme inhibitor^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
K562	EC₅₀	0.87 nM Compound: Ponati Link-1-24	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay	[PMID: 37849551]
K562	EC₅₀	26.29 nM Compound: Ponati Link-1-24	Antiproliferative activity against human K562 cells expressing ABL T315I mutant assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay Antiproliferative activity against human K562 cells expressing ABL T315I mutant assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay	[PMID: 37849551]

Chemical Information

CAS No. 2941512-45-2
Molecular Weight 2120.73
Formula C₁₀₁H₁₄₄ClF₅N₁₂O₂₉
SMILES

CC1=C(C#CC2=CN=C3N2N=CC=C3)C=C(C(NC4=CC=C(CN5CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C6CCN(C7=C(C8=CC=NN8)C=C(C(NC9=CC=C(OC(F)(Cl)F)C=C9)=O)C=N7)CC6)=O)=O)CC5)C(C(F)(F)F)=C4)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robert B. Kargbo. Expanding the Chemical Space: New Approach to Cell-Permeable Drugs. ACS Med. Chem. Lett. 2023, 14, 10, 1329-1330.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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