2. Neuronal Signaling
  3. α-synuclein
  4. PQM-164

PQM-164 (Compound 3e) has antioxidant activity (IC50: 0.93 μM for DPPH radical). PQM-164 shows anti-inflammatory activity against 6-OHDA (HY-B1081A)-induced neuronal damage in activated microglial cells. PQM-164 decreases the accumulation of α-synuclein. PQM-164 promotes nuclear translocation of Nrf2 and its transcriptional activity. PQM-164 can be used for research of Parkinson’s disease.

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PQM-164

PQM-164 Chemical Structure

CAS No. : 2226535-25-5

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PQM-164 Related Antibodies

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α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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Description

PQM-164 (Compound 3e) has antioxidant activity (IC50: 0.93 μM for DPPH radical). PQM-164 shows anti-inflammatory activity against 6-OHDA (HY-B1081A)-induced neuronal damage in activated microglial cells. PQM-164 decreases the accumulation of α-synuclein. PQM-164 promotes nuclear translocation of Nrf2 and its transcriptional activity. PQM-164 can be used for research of Parkinson’s disease[1].

IC50 & Target

α-synuclein Aggregation

 

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
128.85 μM
Compound: 51c
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTS assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTS assay
[PMID: 32485531]
MCF7 IC50
42.99 μM
Compound: 77
Cytotoxicity against human MCF7 Cells after 48 hrs by MTS assay
Cytotoxicity against human MCF7 Cells after 48 hrs by MTS assay
[PMID: 31129455]
Molecular Weight

342.35

Formula

C18H18N2O5
CAS No.
SMILES

O=C(N/N=C/C1=CC=C(O)C(OC)=C1)/C=C/C2=CC=C(O)C(OC)=C2
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Purity & Documentation
References
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PQM-164 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PQM-1642226535-25-5PQM164PQM 164α-synucleinα-SynParkinson’santioxidantDPPHmicroglial cellInhibitorinhibitorinhibit

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