Propargyl-PEG1-acid
Based on 1 publication(s) in Google Scholar
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 97.0%
- CAS No.: 55683-37-9
- Formula: C6H8O3
- Molecular Weight:128.13
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-130481
Propargyl-PEG4-acidPROTAC Linker -
HY-126975
Propargyl-PEG3-acidADC/PROTAC Linker -
HY-130379
Propargyl-PEG8-acidADC/PROTAC Linker -
HY-118764
Propargyl-PEG2-acidPROTAC/ADC Linker -
HY-101157
Propargyl-PEG5-acidADC Linker -
HY-130386
Propargyl-PEG6-acidADC/PROTAC Linker -
HY-140020
Propargyl-PEG10-acidPEG Derivative -
HY-130383
Propargyl-PEG7-acidADC/PROTAC Linker -
HY-101157R
Propargyl-PEG5-acid (Standard)ADC Linker -
HY-114670
Propargyl-PEG4-aminePROTAC Linker -
HY-128716B
Pomalidomide-PEG3-C2-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-141371
Bromo-PEG2-CH2-Boc
Publications Citing Use of MedChemExpress (MCE) Propargyl-PEG1-acid
MoreAll PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 55683-37-9
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Appearance Liquid (Density: 1.140 g/cm3)
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Molecular Weight 128.13
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Formula C6H8O3
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Color Colorless to light yellow
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SMILES
O=C(O)CCOCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma. [Abstract]2022 Oct 8:624:53-58. PMID: 35932580
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (390.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 7.8046 mL | 39.0229 mL | 78.0457 mL | 195.1143 mL |
| 5 mM | 1.5609 mL | 7.8046 mL | 15.6091 mL | 39.0229 mL | |
| 10 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | 19.5114 mL | |
| 15 mM | 0.5203 mL | 2.6015 mL | 5.2030 mL | 13.0076 mL | |
| 20 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL | 9.7557 mL | |
| 25 mM | 0.3122 mL | 1.5609 mL | 3.1218 mL | 7.8046 mL | |
| 30 mM | 0.2602 mL | 1.3008 mL | 2.6015 mL | 6.5038 mL | |
| 40 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8779 mL | |
| 50 mM | 0.1561 mL | 0.7805 mL | 1.5609 mL | 3.9023 mL | |
| 60 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2519 mL | |
| 80 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4389 mL | |
| 100 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9511 mL |
Propargyl-PEG1-acid Related Classifications
HY-130504 Related Classifications
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