2. PROTAC
  3. PROTAC Linkers
  4. Propynol Ethoxylate

Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propynol Ethoxylate Chemical Structure

Propynol Ethoxylate Chemical Structure

CAS No. : 3973-18-0

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Based on 1 publication(s) in Google Scholar

Propynol Ethoxylate Related Antibodies

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Description

Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propynol Ethoxylate Related Antibodies
Molecular Weight

100.12

Formula

C5H8O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

COA (241 KB)

Handling Instructions (2659 KB)
References
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Propynol Ethoxylate Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propynol Ethoxylate3973-18-0PROTAC LinkersInhibitorinhibitorinhibit

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