Protein kinase inhibitor 8
Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 926319-75-7
- Formula: C21H37N7O3
- Molecular Weight:435.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CaMK II |
Chemical Information
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CAS No. 926319-75-7
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Molecular Weight 435.56
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Formula C21H37N7O3
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SMILES
O=C(OC(C)(C)C)NCCCCCCNC1=C2N=CN(C(C)C)C2=NC(NCCO)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yang J, et al. PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model. Neurochem Res. 2024 May;49(5):1226-1238. [Content Brief]
[2]. Scheiter M, et al. Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Front Immunol. 2013 Mar 18;4:66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protein kinase inhibitor 8 Related Classifications
HY-111093 Related Classifications
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