Cadherin-5
Cadherin-5, widely called VE-cadherin and encoded by CDH5, is the endothelium-specific classical cadherin that defines vascular adherens junctions. Homophilic VE-cadherin bonds control endothelial monolayer integrity, and their regulated disassembly governs vascular permeability. The cytoplasmic tail binds p120-catenin and beta-catenin, and VE-cadherin forms complexes with VEGFR-2 that amplify VEGF signaling, tying adhesion directly to angiogenic sprouting. Genetic ablation in mice blocks vascular remodeling and causes embryonic lethality. Because VE-cadherin also stabilizes nascent tumor vessels, antibodies and inhibitors directed at the molecule are explored as vascular-disrupting and anti-angiogenic agents. The junctional molecule is therefore central to both developmental angiogenesis and vascular normalization strategies in tumors.
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Cadherin-5 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
