Other-Unique
This category collects protein kinases that are too divergent to join any established family in the kinome. Two representative members are POMK (SgK196), a Golgi enzyme that phosphorylates the O-linked mannose of alpha-dystroglycan and whose mutations cause a limb-girdle muscular dystrophy with brain involvement, and STK31 (SgK396), a germ cell-restricted kinase of largely unknown function. Because these enzymes lack close paralogs, structure, regulation and substrate selection must be worked out individually rather than by analogy to a family consensus. Recombinant versions are consequently valuable for antibody generation, activity profiling and for testing whether orphan kinomes harbor druggable sites.
