PDK2/PDHK2
Among the four PDH kinases, PDK2 is the most abundantly and ubiquitously expressed isozyme and is often the dominant regulator of pyruvate dehydrogenase flux in tissues such as liver and kidney. It phosphorylates Ser293 of the PDH complex E1alpha subunit to block entry of glycolytic carbon into mitochondria, and its crystal structures have made it the reference enzyme for understanding lipoyl-domain recognition and allosteric effector regulation within the family. PDK2 is potently inhibited by dichloroacetate (DCA), the prototypical PDH-kinase drug, which is used clinically in lactic acidosis. Recombinant PDK2 is widely employed in DCA-class inhibitor screening and metabolic studies.
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PDK2/PDHK2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
