WNK3
WNK3 is an epithelially expressed chloride-sensitive kinase of the WNK family, prominent in the kidney distal tubule as well as in gastrointestinal and other ion-transporting epithelia. It modulates a broad panel of transport proteins, including the thiazide-sensitive NCC, the sodium-chloride cotransporter NKCC2, the potassium channel ROMK, and the calcium channel TRPV5, largely through the SPAK/OSR1 signaling module and through trafficking control. WNK3 thereby tunes sodium, potassium and calcium handling in concert with WNK1 and WNK4. Missense mutations in the WNK3 kinase domain cause pseudohypoaldosteronism type II with hypertension and hyperkalemia. Recombinant WNK3 is a tool for renal transport and blood-pressure studies.
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WNK3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
