PSMA-R2
PSMA ligand 2 is a prostate specific membrane antigen (PSMA) ligand with a glutamate-urea-lysine (GUL) moiety. PSMA ligand 2 can be efficiently labeled with radioactive nuclides such as 68Ga and 177Lu and specifically binds to PSMA-positive tumor cells. PSMA ligand 2 can be used for imaging of PSMA-expressing tumors or cells via PET or SPECT imaging. PSMA ligand 2 can be used for the research of prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2576410-20-1
- Formula: C41H63BrN8O15
- Molecular Weight:987.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PSMA ligand 2 (68Ga‑PSMA‑R2) (4.5 MBq; i.v.; single dose) exhibits high uptake in PSMA-positive prostate tumors in athymic nude mice at 1 hour post-injection, with a tumor-to-kidney ratio of 5[1].
PSMA ligand 2 (111 MBq; i.v.; single dose) significantly reduces PSMA-positive prostate tumor volumes in athymic nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice bearing PC3-PIP[1]
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Dosage:111 MBq
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Administration:i.v.; single dose
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Result:Reduced tumor volume.
Chemical Information
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CAS No. 2576410-20-1
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Molecular Weight 987.89
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Formula C41H63BrN8O15
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SMILES
OC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCN(C(CCCCCNC(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O)CC2=CC=C(C=C2)Br)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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