PtdIns-(3,4,5)-P3-biotin sodium 

PtdIns-(3,4,5)-P3-biotin sodium is a Biotin-labeled PtdIns-(3,4,5)-P3 (PI(3,4,5)P3). PI(3,4,5)P3 is a substrate of nuclear phosphatidylinositol 5-phosphatase (PIP5Pase). PI(3,4,5)P3 binds to the N-terminus of RAP1 (repressor activator protein 1) and controls its DNA binding activity^[1].

Transient inactivation of PIP5Pase results in the accumulation of nuclear PI(3,4,5)P3, which binds RAP1 and displaces it from expression sites (ESs), activating transcription of silent ESs and variant surface glycoprotein (VSG) switching^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1155.78

C₃₅H₆₁N₃Na₄O₂₄P₄S

1415684-80-8

Solid

White to off-white

O=P(O)(O[Na])O[C@H]1[C@@H]([C@H]([C@@H]([C@@H]([C@@H]1OP(O)(O[Na])=O)O)OP(OC[C@@H](COC(CCCCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)OC(CCCCCCC)=O)(O[Na])=O)O)OP(O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

• [1]. Touray AO, et al. PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. Elife. 2023 Nov 29;12:RP89331.  [Content Brief]