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Cat. No.: HY-189266

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PTP1B-IN-36

PTP1B-IN-36 is a PTP1B inhibitor (IC₅₀ 0.70 μM) and a SHP2-E76K inhibitor (IC₅₀ 0.36 μM). PTP1B-IN-36 exhibits broad-spectrum inhibitory activity against PTP family enzymes, including TCPTP, SHP1-PTP, SHP2-PTP, and SHP1-WT. PTP1B-IN-36 shows anticancer activity against osteosarcoma. PTP1B-IN-36 can be used for research on osteosarcoma.

For research use only. We do not sell to patients.

Formula: C₁₄H₉N₃O₃
Molecular Weight:267.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PTP1B-IN-36 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC50	157.24 μM	Antiproliferative activity against human U2OS osteosarcoma cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay. Antiproliferative activity against human U2OS osteosarcoma cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.	42612262

In Vitro

PTP1B-IN-36 (Compound 5a) (50 μM; 20 min) exhibits broad-spectrum PTP inhibition, achieving greater than 90% inhibition of PTP1B, TCPTP, SHP2-PTP, SHP2-E76K, and SHP1-WT, with 77.05% inhibition of SHP1-PTP^[1].
PTP1B-IN-36 (0.07-50.0 μM; 72 h) exhibits dose-dependent antiproliferative activity in U2OS human osteosarcoma cells with an IC₅₀ of 157.24 μM, which is significantly less potent than its enzymatic inhibition due to unfavorable physicochemical properties limiting membrane permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

U2OS
Concentration:

0.07-50.0 μM
Incubation Time:

72 h
Result:

Exhibited dose-dependent cytotoxicity with an IC₅₀ of 157.24 μM.

Chemical Information

Molecular Weight 267.24
Formula C₁₄H₉N₃O₃
SMILES

OC(C1=CC(OC(C2=NC3=C(C=CC=C3)N2)=C4)=C4N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Milaneh S, et al. Design, synthesis, and biological evaluation of novel furo[3,2-b]pyrrole-benzimidazole series as potential protein tyrosine phosphatase (PTPs) inhibitors. Bioorganic chemistry. 2026 Oct 05;181:110373.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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