2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties

  • Free Radic Biol Med. 2000 Feb 1;28(3):403-8. doi: 10.1016/s0891-5849(99)00254-3.
G Olive  1 ,  A Mercier ,  F Le Moigne ,  A Rockenbauer ,  P Tordo
Affiliations
  • 1. Laboratoire Structure et Réactivité des Espèces Paramagnétiques, CNRS UMR 6517, "Chimie, Biologie et Radicaux Libres", Universités d'Aix-Marseille I et III, Centre de St Jérôme, Service 521, Marseille, France.
PMID: 10699752 DOI: 10.1016/s0891-5849(99)00254-3
Abstract

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-N-oxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and Other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O(2)(-*) spin adduct was estimated to be about five times more persistent than its DMPO analogue. Furthermore, its decay does not produce the EMPO/HO&z.rad; adduct.

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