Constituents of the root bark of Severinia buxifolia collected in Hainan

  • J Nat Prod. 2001 Aug;64(8):1040-3. doi: 10.1021/np0005309.
T S Wu  1 ,  C M Chen ,  F W Lin
Affiliations
  • 1. Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, 701, Republic of China. [email protected]
PMID: 11520222 DOI: 10.1021/np0005309
Abstract

Two new tetranortriterpenoids, 7-isovaleroylcycloseverinolide (1) and 7-isovaleroylcycloepiatalantin (2), together with 28 known compounds, were isolated and characterized from the root bark of Severinia buxifolia collected in Hainan. The structures of 1 and 2 were elucidated on the basis of spectral evidence including 2D NMR and X-ray techniques. The cytotoxicity of several acridone alkaloid isolates (3-8) was evaluated against a small tumor cell panel.