Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir

  • Antimicrob Agents Chemother. 2001 Oct;45(10):2925-7. doi: 10.1128/AAC.45.10.2925-2927.2001.
J J McSharry  1 ,  A McDonough ,  B Olson ,  S Hallenberger ,  J Reefschlaeger ,  W Bender ,  G L Drusano
Affiliations
  • 1. Center for Immunology and Microbial Diseases, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208, USA. [email protected]
PMID: 11557492 DOI: 10.1128/AAC.45.10.2925-2927.2001
Abstract

BAY38-4766 and BAY43-9695 are nonnucleosidic compounds with activities against human cytomegalovirus (HCMV). Two phenotypic assays were used to determine the drug susceptibilities of 36 HCMV clinical isolates to the BAY compounds and ganciclovir. Using either assay, both BAY compounds at a concentration of approximately 1 microM inhibited the replication of all 36 HCMV clinical isolates, including 11 ganciclovir-resistant clinical isolates, by 50%.

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