Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis

  • J Nat Prod. 2001 Sep;64(9):1162-8. doi: 10.1021/np010030v.
L P Mai  1 ,  F Guéritte ,  V Dumontet ,  M V Tri ,  B Hill ,  O Thoison ,  D Guénard ,  T Sévenet
Affiliations
  • 1. Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
PMID: 11575949 DOI: 10.1021/np010030v
Abstract

An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known Anthraquinones and anthrones, one new rhamnosylanthraquinone, 3'-O-acetylfrangulin A (8), several new rhamnosylanthrones, the prinoidin-emodin bianthrones (9A-D), the prinoidin bianthrones (10A,B), and the rhamnepalins (11A-C). A structure-cytotoxic activity relationship study was performed on these isolates and some semisynthetic derivatives.