An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius

  • Phytomedicine. 2001 Nov;8(6):489-91. doi: 10.1078/S0944-7113(04)70071-9.
K Shrestha  1 ,  A H Banskota ,  S Kodata ,  S P Shrivastava ,  G Strobel ,  M B Gewali
Affiliations
  • 1. Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
PMID: 11824527 DOI: 10.1078/S0944-7113(04)70071-9
Abstract

An ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in chloroform-soluble fraction. Nagilactone C, the major constituent of this fraction was isolated and characterized by using NMR, IR and FAB-MS spectroscopic methods. Nagilactone C possessed potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively. Hence, nagilactone C could be the active constituent present in this plant.

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